15. Cho HS, Lee MH, Lee JW, et al. Both the area covered by melasma and the intensity of the pigment were significantly reduced. 67. Extensive research into a plant extract Pycnogenol® from the French Maritime pine tree has shown that this collection of phyto-molecules not only rejuvenates skin elasticity and reduces collagen degradation, but works internally to lower blood glucose levels, increase nitric oxide to dilate blood vessels, restore capillary health, and normalize blood pressure. 2011 Jan;6(1):1-11. Pycnogenol® protects neurons from amyloid-beta peptide-induced apoptosis. 15 At the end of the study, the size of their unwanted skin pigmentation was significantly reduced. Remember, these spots always want to come back, so even after your melasma and brown spots are gone, keep treating your skin a couple of times a week, and don't forget to take your Pycnogenol. The richness of the diverse human experience is reflected in the wide array of skin tones found around the world. Oral Pycnogenol® at 150 mg/day can produce complete healing of ulcers in up to 85% of patients.42,43. After suffering with Raynaud's phenomenon for many years, I decided to try Pycnogenol after reading the study you recently cited. 35. More information at www.ConsumerLab.com/survey. 2009 Dec;25(6):537-40. Known as melasma, or chloasma, it’s most common in pregnancy but the contraceptive pill can also cause hyperpigmentation. COVID-19 is an emerging, rapidly evolving situation. I will take a look at this treatment in the following article. Kim YJ, Kim YA, Yokozawa T. Pycnogenol® modulates apoptosis by suppressing oxidative stress and inflammation in high glucose-treated renal tubular cells. Pine bark extract reduces platelet aggregation. 2006 Jul;12(3):318-23. Pycnogenol® further prevents wrinkling by protecting vital skin proteins from degradation, while increasing their natural production.11-13 These proteins break down by UV-induced inflammatory processes caused by sun exposure. In one study, researchers showed that Pycnogenol® supplementation (75 to 125 mg/day) protected human volunteers from damaging sunburn after exposure to UV light.9 In other words, Pycnogenol® acts as an internal sun-screen, reducing your exposure to this major cause of wrinkles. Skin Pharmacol Physiol. 19. Gen Physiol Biophys. Grether-Beck S, Marini A, Jaenicke T, Krutmann J. Melasma . Prevention and treatment information (HHS). This study provides skin-physiological and for the first time molecular evidence that Pycnogenol supplementation benefits human skin by increasing skin hydration and skin elasticity. I still get melasma but treat it with Pycnogenol, Heliocare, tretinoin 0.1%, MSM, azaleic acid, vitamin C and alternate 4% hydroquinone with kojic acid and arbutin. On a Monday two days before my flight, I took one dose of pycnogenol, as recommended by John. The researchers concluded that Pycnogenol®, a unique natural mixture of health-promoting substances, was able to rejuvenate the experimental animals' biology in ways that no single drug, or even nutrient, could do. Pycnogenol is a patented formulation of Pine Bark Extract which is standardized to 65-75% Procyanidin compounds by weight. I've been asked if taking pycnogenol shows any promise in treating this condition or at least in making it look somewhat better. Deciem says: Pycnogenol® is a very unique, very powerful plant-derived antioxidant that protects against environmental stressors before they are able to cause damage to the skin. 2015 Mar;144:94-103. doi: 10.1016/j.jphotobiol.2014.12.025. Free Radic Biol Med. 37. Figure 2: After 6 weeks supplementation with a Pycnogenol®–containing supplement, skin elasticity improved by 9% over the placebo group.14. Brain Res Mol Brain Res. Pycnogenol® enhances immune and haemopoietic functions in senescence-accelerated mice. After standardized measurements of area and degree of melasma pigmentation, each woman took 25 milligrams of pycnogenol three times daily for 30 days. 2011 Sep;53(3 Suppl 1):65-70. A malfunctioning endothelium can't properly control blood flow and pressure. Other areas of skin became lighter as well, as the density of pigment decreased. Epub 2012 Aug 1. 2012;25(2):86-92. Procyanidins are chain-like structures consisted of catechins similar to some found in green tea (the green tea catechins that do not have 'gallate' in their names). The skin-physiological improvement was accompanied by a significant increase in the mRNA expression of hyaluronic acid synthase-1 (HAS-1), an enzyme critically involved in the synthesis of hyaluronic acid, and a noticeable increase in gene expression involved in collagen de novo synthesis. Phytother Res. Groten K, Marini A, Grether-Beck S, Jaenicke T, Ibbotson SH, Moseley H, Ferguson J, Krutmann J. I thought it would go away, but after two years, I realized that it wasn’t going anywhere. Pycnogenol supplementation may thus be useful to counteract the clinical signs of skin aging. These specially bred mice show the typical effects of aging, such as decreased immune function, poor blood cell production, and learning and memory deficits. Hypertens Res. 14. Dvorakova M, Sivonova M, Trebaticka J, et al. 20. The clinical cases listed below are hyperpigmentation cases treated by certified dermatologists and healthcare professionals. 60. By no means am I an expert on this topic but because of my own issues, I have researched it and experimented with different treatments. Melasma Another study in 2012 showed that Pycnogenol® alone, at a dose of 75 mg/day, increased skin hydration by 8% after just 6 weeks; in women with dry skin at baseline the increase was 21%.11 Skin elasticity increased, and skin fatigue decreased significantly in this study as well, further lowering the wrinkling risk. Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women. 2008 May;28(5):315-20. Before & After results. J Cardiovasc Pharmacol. Cell Mol Life Sci. J Cosmet Dermatol. Pycnogenol has been reported to be effective in treating melasma. 2. 24. the melasma area index, which was based on assessing the diameter of the lesional skin area by means of a ruler. Oxidant stress underlies neurocognitive disorders like Alzheimer's and Parkinson's diseases, as well as atherosclerosis and cancer. Other areas of skin … Belcaro G, Cesarone MR, Errichi S, et al. Within 1 week of stopping Obagi and moving on to my new melasma obsession Lumixyl the melasma came back 100% + 10% and that means more melasma. Pycnogenol is a dietary supplement that is used to help a whole host of health needs but as a side effect, it was discovered that it also had some pretty powerful anti-aging qualities too. Melasma before after pictures provided by Q Esthetics Laser Clinic, contact us to see more amazing before after photos of laser melasma treatment. If using other products, it would be applied after your water-based serums and before oils or heavier creams. 42. Armed with this insight, scientists began to explore other ways that Pycnogenol® fights the primary aging mechanisms and slows the aging process in many different organs and systems at once. 2008 Apr;22(4):518-23. Materials and methods: For this purpose 20 healthy postmenopausal women were supplemented with Pycnogenol for 12 weeks. Life Extension does not provide medical advice, diagnosis, or treatment. Please be careful of adverts that may follow you on social media with amazing results. Nutr Res. bought 50 mg capsules of a supplement : Pycnogenol. Pycnogenol enhances NO (nitric oxide) production which leads to an improvement in blood vessel dilation and an increase in blood flow and oxygen supply to muscles. Rohdewald P. Pycnogenol® protects DNA against oxidative damage in vivo. If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027. 4. Taken pycnogenol, cysteine, glucosamine, antioxidants and vitamins. 8. Any change in hormonal status with higher levels of estrogen is thought to trigger and aggravate the condition (i.e. 2008 Dec 1;45(11):1510-9. In this condition, chronically elevated pressures within the heart cause the muscle to become floppy and ineffective. Phytother Res. However, the benefit of taking 100 mg or 200 mg of Pycnogenol® was even more dramatic. The incidence of type II diabetes is skyrocketing in many countries worldwide.67 Chronically elevated blood sugar causes debilitating damage to just about every bodily system. D’Andrea G. Pycnogenol®: a blend of procyanidins with multifaceted therapeutic applications? Before supplementation, patients could walk only about 223 feet; that distance increased 66% to 650 feet after treatment. Nocun M, Ulicna O, Muchova J, Durackova Z, Watala C. French maritime pine bark extract Pycnogenol® reduces thromboxane generation in blood from diabetic male rats. Pycnogenol® has been shown to slow declines in nerve conduction velocity, even under diabetic conditions.36.
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